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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Antiallergic agents, excl. corticosteroids
cromoglicic acid, combinations
R01AC51
Forms & Strengths
- Nasal spray: Cromolyn sodium 2% combined with xylometazoline hydrochloride 0.05%
Adult Dosing
- 1 spray in each nostril 3 to 4 times daily as needed for allergic rhinitis symptoms
Pediatric Dosing
- Not recommended for children under 12 years of age due to vasoconstrictor component
Indications
- Symptomatic relief of allergic rhinitis (e.g., seasonal allergic rhinitis / hay fever)
Mechanism of Action
- Cromoglicic acid stabilizes mast cells preventing the release of histamine and leukotrienes
- Xylometazoline acts as an alpha-adrenergic agonist causing nasal mucosal vasoconstriction to reduce congestion
Contraindications
- Hypersensitivity to cromoglicic acid, xylometazoline, or any component
- Rhinitis sicca
- Angle-closure glaucoma
- History of trans-sphenoidal hypophysectomy or nasal surgery exposing dura mater
- Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuation
Adverse Reactions
- Transient nasal stinging or burning
- Sneezing
- Nasal mucosal dryness
- Epistaxis
- Rebound congestion (rhinitis medicamentosa) with prolonged use of the decongestant component
- Headache
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): May precipitate severe hypertensive crisis
- Tricyclic antidepressants: May potentiate the pressor effects of xylometazoline
- Sympathomimetic agents: May enhance cardiovascular adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use