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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Corticosteroids
tixocortol, combinations
R01AD57
Forms & Strengths
- Nasal spray suspension: tixocortol pivalate combined with decongestants or other active ingredients (strength varies by proprietary product)
Adult Dosing
- 1-2 sprays into each nostril 2 to 4 times daily as needed for acute or allergic rhinitis symptoms
Pediatric Dosing
- Safety and efficacy in children under 6 years generally not established; use age-appropriate formulations and follow specific product labeling
Indications
- Symptomatic relief of seasonal and perennial allergic rhinitis
- Vasomotor rhinitis
- Adjuvant treatment of acute upper respiratory tract congestion
Mechanism of Action
- Tixocortol pivalate is a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties, exerting local action on nasal mucosa
- Combined agents typically provide rapid decongestant or antihistaminic effects
Contraindications
- Hypersensitivity to tixocortol or any components of the formulation
- Untreated localized nasal fungal or bacterial infections
- Recent nasal surgery or trauma
Adverse Reactions
- Transient nasal burning, stinging, or dryness
- Epistaxis (nosebleeds)
- Local irritation or sneezing immediately after application
- Rare systemic corticosteroid effects with prolonged high-dose use
Drug Interactions
- Strong CYP3A4 inhibitors (e.g., ritonavir, ketoconazole) may increase systemic exposure
- Concurrent use with other systemic or nasal corticosteroids may increase the risk of systemic corticosteroid side effects
Curated Content: Needs Vetting Before Put to Clinical Use