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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Corticosteroids
mometasone, combinations
R01AD59
Forms & Strengths
- Nasal spray: Mometasone furoate 50 mcg per actuation combined with azelastine hydrochloride 137 mcg per actuation
Adult Dosing
- Allergic rhinitis: 1 spray in each nostril twice daily
Pediatric Dosing
- Children >= 12 years: 1 spray in each nostril twice daily
- Children < 12 years: Safety and efficacy not established
Indications
- Relief of symptoms of seasonal allergic rhinitis in patients 12 years of age and older
Mechanism of Action
- Mometasone furoate is a glucocorticoid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties
- Azelastine hydrochloride is a selective H1-receptor antagonist and mast cell stabilizer with anti-inflammatory activity
- Combination provides complementary local action targeting multiple pathways of the allergic inflammatory cascade
Contraindications
- Hypersensitivity to mometasone, azelastine, or any excipients in the formulation
- Untreated localized fungal infections involving the nasal mucosa
Adverse Reactions
- Dysgeusia (bitter taste)
- Epistaxis
- Nasal discomfort
- Headache
- Somnolence
Drug Interactions
- Strong CYP3A4 inhibitors (e.g., ritonavir, ketoconazole): May increase systemic exposure of mometasone furoate
- CNS depressants (e.g., alcohol, sedatives): May potentiate somnolence due to systemic absorption of azelastine
Curated Content: Needs Vetting Before Put to Clinical Use