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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Other nasal preparations
calcium hexamine thiocyanate
R01AX01
Forms & Strengths
- Nasal spray 0.1% (hexamine 1 mg + thiocyanate 0.5 mg per spray)
- Nasal drops 0.2% solution
Adult Dosing
- 2 sprays per nostril every 4‑6 h
- Maximum 6 sprays in 24 h
Pediatric Dosing
- Children ≥6 y: 1‑2 sprays per nostril every 4‑6 h
- Maximum 4 sprays in 24 h
- Children <6 y: not recommended
Indications
- Temporary relief of nasal congestion due to common cold
- Acute rhinitis and sinusitis
- Allergic rhinitis
Mechanism of Action
- Topical vasoconstriction by hexamine reduces mucosal edema
- Calcium thiocyanate promotes mucociliary clearance and secretolysis
Contraindications
- Hypersensitivity to calcium hexamine thiocyanate or excipients
- Severe hypertension
- Narrow‑angle glaucoma
- Recent nasal or sinus surgery
- Infants <2 y
Adverse Reactions
- Local burning or stinging sensation
- Nasal dryness or irritation
- Epistaxis
- Rhinorrhea
- Rebound congestion with prolonged use
- Rare systemic effects (e.g., tachycardia)
Drug Interactions
- Minimal systemic absorption; low interaction potential
- Avoid concomitant use with other topical nasal decongestants (additive vasoconstriction)
- Caution with systemic sympathomimetics or MAO‑inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use