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benzydamine

R02AX03

Forms & Strengths

Oral rinse solution 0.15% (w/v)
Oral spray 0.15% solution
Lozenges 0.5% (w/v) benzydamine
Gels/cream 0.5% for oral mucosa
Topical ointment 0.5% for skin

Adult Dosing

Oral rinse: 15 mL, swish 30 s, expectorate 3–4×/day
Oral spray: 1–2 sprays (≈0.2 mL) 3–4×/day
Lozenges: 1–2 lozenges every 2–3 h, max 8/day
Topical gel: apply thin layer to affected mucosa 3–4×/day
Skin ointment: thin film 2–3×/day

Pediatric Dosing

Children ≥6 yr: oral rinse 5 mL, swish 30 s, 2–3×/day
Children ≥6 yr: oral spray 1 spray (≈0.1 mL) 2–3×/day
Lozenges not recommended <12 yr
Topical gel: small amount applied 2×/day
Contraindicated <6 yr

Indications

Acute sore throat (pharyngitis, tonsillitis)
Oral mucositis and stomatitis
Post‑operative oral pain
Dental pain and gingivitis
Topical relief of minor skin inflammation and irritations

Mechanism of Action

Local anti‑inflammatory: inhibits prostaglandin synthesis via COX‑independent pathway
Reduces cytokine release (TNF‑α, IL‑1β) and NF‑κB activation
Membrane stabilizer with analgesic effect
Mild local anesthetic by blocking Na⁺ channels
Antimicrobial activity against oral flora

Contraindications

Known hypersensitivity to benzydamine or excipients
Children <6 yr (insufficient safety data)
Severe hepatic impairment (caution, limited systemic absorption)
Concurrent use of other local anesthetics on same site

Adverse Reactions

Transient burning or stinging sensation
Altered taste (metallic/ bitter)
Nausea or vomiting if excessive swallow
Localized erythema, edema, or rash
Rare hypersensitivity (urticaria, angioedema)

Drug Interactions

Additive local anesthetic effect with other topical anesthetics
Avoid concomitant use of other NSAID mouthwashes to reduce mucosal irritation
Caution with anticoagulants if large amounts swallowed (theoretical increased bleeding risk)
Alcohol‑containing formulations may potentiate CNS depression with CNS depressants

Curated Content: Needs Vetting Before Put to Clinical Use