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RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS, INHALANTS › Selective beta-2-adrenoreceptor agonists
tretoquinol
R03AC09
Forms & Strengths
- Oral tablets 1 mg
- Oral syrup 0.05%
Adult Dosing
- 1 to 2 mg orally three times daily
- Adjust dose based on clinical response and tolerability
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established
- Use with caution and weight-based dosing if prescribed by a specialist
Indications
- Bronchial asthma
- Chronic bronchitis
- Emphysema with bronchospasm
Mechanism of Action
- Non-selective beta-2 adrenergic receptor agonist
- Stimulates intracellular adenylate cyclase, increasing cAMP
- Relaxes bronchial smooth muscle and inhibits release of hypersensitivity mediators
Contraindications
- Hypersensitivity to tretoquinol or other sympathomimetic amines
- Pre-existing tachyarrhythmias
- Hypertrophic obstructive cardiomyopathy
Adverse Reactions
- Palpitations
- Tachycardia
- Tremors
- Nervousness
- Nausea and dry mouth
Drug Interactions
- Other sympathomimetic agents may potentiate cardiovascular toxicity
- Beta-blockers antagonize the bronchodilatory effects
- Monoamine oxidase inhibitors and tricyclic antidepressants may potentiate vascular effects
Curated Content: Needs Vetting Before Put to Clinical Use