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diprophylline and adrenergics

R03DB01

Forms & Strengths

Combination oral tablets containing diprophylline and an adrenergic bronchodilator
Combination oral syrups containing diprophylline and an adrenergic bronchodilator

Adult Dosing

1 tablet or appropriate syrup dose orally every 6 to 8 hours as needed
Dosage must be individualized based on clinical response and patient tolerance to the adrenergic component

Pediatric Dosing

Safety and efficacy in pediatric patients under 12 years of age not well established
Pediatric dosing must be calculated strictly by weight and clinical response under specialist supervision

Indications

Symptomatic relief of bronchial asthma
Reversible bronchospasam associated with chronic bronchitis and emphysema

Mechanism of Action

Diprophylline acts as a xanthine derivative, causing bronchodilator and smooth muscle relaxation via phosphodiesterase inhibition
Adrenergic component stimulates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation and bronchodilation

Contraindications

Hypersensitivity to xanthines, sympathomimetic amines, or any component of the formulation
Active peptic ulcer disease
Severe cardiovascular disease, cardiac arrhythmias, or tachyarrhythmias
Concurrent use with monoamine oxidase inhibitors (MAOIs)

Adverse Reactions

Tachycardia, palpitations, and cardiac arrhythmias
Nervousness, tremor, anxiety, and dizziness
Nausea, vomiting, epigastric pain, and gastrointestinal irritation
Headache, insomnia, and muscle cramps

Drug Interactions

Enhanced sympathetic nervous system toxicity when co-administered with other sympathomimetic agents
Severe hypertension or hypertensive crisis with MAOIs or tricyclic antidepressants
Hypokalemia risk increased with concurrent loop or thiazide diuretics
Additive CNS stimulation with other central nervous system stimulants

Curated Content: Needs Vetting Before Put to Clinical Use