← Search & browse all drugs
RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS › Expectorants
cineole
R05CA13
Forms & Strengths
- Soft gelatin capsules: 100 mg
- Soft gelatin capsules: 200 mg
- Nasal spray/solution: 5%
Adult Dosing
- Acute bronchitis: 200 mg orally 3 to 4 times daily
- Sinusitis: 200 mg orally 3 to 4 times daily
- Adjunctive therapy in asthma: 200 mg orally 3 times daily
Pediatric Dosing
- Children aged 12 years and older: 100 mg orally 3 times daily
- Not recommended for children under 6 years due to risk of laryngospasm
Indications
- Symptomatic treatment of acute bronchitis
- Adjunctive treatment of acute and chronic sinusitis
- Symptomatic relief in common cold and upper respiratory tract infections
Mechanism of Action
- Exerts secretolytic and mucolytic effects in the respiratory tract
- Possesses anti-inflammatory properties by inhibiting cytokine production
- Bronchospasmolytic action mediated via relaxation of bronchial smooth muscle
Contraindications
- Hypersensitivity to cineole or eucalyptus oil
- Whooping cough (pertussis) or pseudocroup
- Children under 2 years of age due to risk of glottal edema or bronchospasm
Adverse Reactions
- Gastrointestinal distress (nausea, vomiting, diarrhea)
- Hypersensitivity reactions (urticaria, rash, pruritus)
- Rarely: bronchospasm in susceptible patients
Drug Interactions
- May induce hepatic cytochrome P450 enzymes (potential reduction in efficacy of concurrently administered drugs)
- No major clinically significant pharmacokinetic drug interactions documented with standard dosing
Curated Content: Needs Vetting Before Put to Clinical Use