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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Opium alkaloids and derivatives
thebacon
R05DA10
Forms & Strengths
- Oral tablets 10 mg
- Oral syrup 5 mg/5 mL
- Suppository 15 mg
Adult Dosing
- 10 mg to 20 mg orally every 4 to 6 hours as needed
- Maximum daily dose not to exceed 120 mg
Pediatric Dosing
- Children 6-12 years: 5 mg orally every 6 hours as needed
- Children under 6 years: Safety and efficacy not established
Indications
- Symptomatic relief of non-productive cough
- Suppression of acute cough associated with upper respiratory tract infections
Mechanism of Action
- Acts centrally on the cough center in the medulla to elevate the threshold for coughing
- Structural analog of codeine with weak opioid receptor affinity and minimal analgesic activity at therapeutic doses
Contraindications
- Hypersensitivity to thebacon or other opioid derivatives
- Concomitant use with MAO inhibitors or within 14 days of cessation
- Severe respiratory depression
- Acute asthma attack or significant chronic obstructive pulmonary disease
Adverse Reactions
- Drowsiness and dizziness
- Nausea and vomiting
- Constipation
- Mild respiratory depression at high doses
- Pruritus and rash due to histamine release
Drug Interactions
- Increased CNS depression and respiratory depression when combined with alcohol, sedatives, or hypnotics
- Risk of severe serotonin syndrome or hypertensive crisis with MAO inhibitors
- Potentiation of adverse effects when used alongside other strong central nervous system depressants
Curated Content: Needs Vetting Before Put to Clinical Use