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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
benproperine
R05DB02
Forms & Strengths
- Oral syrup: 4 mg/mL
- Oral tablets: 20 mg
- Capsules: 20 mg
Adult Dosing
- 20 mg orally 3 times daily
- Maximum daily dose: 60 mg
Pediatric Dosing
- Children < 2 years: Not recommended
- Children 2-6 years: 5 mg to 10 mg orally 3 times daily
- Children > 6 years: 10 mg to 20 mg orally 3 times daily
Indications
- Symptomatic treatment of non-productive (dry) cough
Mechanism of Action
- Acts as a non-narcotic peripheral and central antitussive agent
- Suppresses the cough reflex via action on the cough center in the medulla oblongata and local sensory nerve endings in the respiratory tract
Contraindications
- Hypersensitivity to benproperine or excipients
- Productive cough with excessive mucus or sputum production
- Severe hepatic impairment
- Pregnancy and lactation (due to insufficient safety data)
Adverse Reactions
- Mild gastrointestinal disturbances (nausea, dyspepsia)
- Drowsiness or dizziness
- Allergic skin reactions (rash, pruritus)
Drug Interactions
- CNS depressants (alcohol, sedatives, hypnotics): May potentiate sedative effects
- Expectorants and mucolytics: May theoretically counteract the intended dry cough suppression
Curated Content: Needs Vetting Before Put to Clinical Use