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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
oxolamine
R05DB07
Forms & Strengths
- Oral syrup: 10 mg/mL
- Oral tablets: 100 mg
- Suppositories: 50 mg
Adult Dosing
- Oral syrup: 20 to 40 mg (2 to 4 mL) 3 to 4 times daily
- Oral tablets: 100 mg 3 times daily
- Suppositories: 50 to 100 mg 2 to 3 times daily
Pediatric Dosing
- Infants (under 2 years): 0.5 to 1 mg/kg or 1 mL syrup 3 times daily
- Children (2 to 6 years): 1 to 2 mL syrup 3 times daily
- Children (over 6 years): 2 to 3 mL syrup or half a tablet 3 times daily
Indications
- Symptomatic treatment of non-productive (dry) cough
- Relief of acute and chronic inflammatory conditions of the upper respiratory tract
Mechanism of Action
- Acts as a peripheral non-narcotic antitussive agent
- Possesses mild local anesthetic properties that soothe the respiratory mucosa
- Exhibits mild anti-inflammatory and bronchodilating activities
Contraindications
- Hypersensitivity to oxolamine or any excipients
- Severe hepatic impairment
- Severe renal impairment
- Peptic ulcer disease (relative contraindication due to potential mucosal irritation)
Adverse Reactions
- Gastrointestinal upset, nausea, or epigastric pain
- Drowsiness or dizziness
- Allergic skin reactions, rash, or pruritus
- Dry mouth
Drug Interactions
- Enhancement of central nervous system depression when co-administered with sedatives or alcohol
- Potential potentiation of other anticholinergic drugs leading to dry mouth and urinary retention
- No major cytochrome P450-mediated drug interactions well-documented
Curated Content: Needs Vetting Before Put to Clinical Use