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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
bibenzonium bromide
R05DB12
Forms & Strengths
- Oral tablet 20 mg
- Syrup 20 mg/5 mL
- Lozenges 5 mg
Adult Dosing
- 20 mg to 40 mg orally 3 to 4 times daily
- Maximum daily dose: 160 mg
Pediatric Dosing
- Children 6-12 years: 10 mg to 20 mg 3 times daily
- Children under 6 years: Safety and efficacy not well established; use with caution
Indications
- Symptomatic relief of non-productive cough
- Acute and chronic bronchitis with irritating cough
Mechanism of Action
- Antitussive agent with peripheral action on the respiratory tract stretch receptors
- Exhibits mild anticholinergic and local anesthetic properties that suppress the cough reflex
Contraindications
- Hypersensitivity to bibenzonium bromide
- Productive cough where suppression may cause mucus retention
- Severe hepatic or renal impairment
Adverse Reactions
- Dry mouth
- Mild gastrointestinal discomfort
- Nausea
- Drowsiness
- Allergic skin reactions
Drug Interactions
- Anticholinergic drugs: May potentiate anticholinergic side effects such as dry mouth and urinary retention
- Central nervous system depressants: Potential additive sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use