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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
droxypropine
R05DB17
Forms & Strengths
- Dropropizine oral syrup 5 mg/mL
- Dropropizine tablets 15 mg
- Dropropizine tablets 30 mg
Adult Dosing
- Syrup 15–30 mg (3–6 mL) 3 times daily
- Tablets 15–30 mg 3 times daily
- Maximum 90 mg per day
Pediatric Dosing
- Ages 2–5 y: 5 mg (1 mL) 3 times daily
- Ages 6–12 y: 10 mg (2 mL) 3 times daily
- Maximum 30 mg per day in children
Indications
- Productive cough due to acute or chronic bronchitis
- COPD exacerbations with sputum retention
- Upper respiratory tract infections with thick mucus
- Sinusitis with muco‑production
Mechanism of Action
- Reduces mucus viscosity by disrupting mucin‑glycoprotein bonds
- Enhances ciliary beat frequency and sputum clearance
Contraindications
- Known hypersensitivity to dropropizine
- Severe bronchial asthma with active bronchospasm
- Infants <2 years of age
- Active pulmonary hemorrhage
Adverse Reactions
- Nausea and vomiting
- Dyspepsia or abdominal discomfort
- Transient rash or urticaria
- Rare hypersensitivity anaphylaxis
Drug Interactions
- Concurrent anticholinergics may diminish mucolytic effect
- Use with other mucolytics/expectants may increase bronchospasm risk
- Caution with CNS depressants (sedatives) due to additive sedation
Curated Content: Needs Vetting Before Put to Clinical Use