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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
combinations
R05DB20
Forms & Strengths
- Syrup: various combinations of antitussives, expectorants, and decongestants
- Oral Solution: multi-ingredient liquid formulations
- Tablets/Capsules: fixed-dose combination products
Adult Dosing
- Varies widely by specific product formulation
- Typically 1-2 tablets or 10-20 mL of liquid every 4 to 6 hours as needed
- Do not exceed maximum daily doses specified by individual product labeling
Pediatric Dosing
- Not recommended in children under 4 years of age due to risk of serious toxicity
- Children 6-12 years: Varies by product, generally half the adult dose
- Always use age-appropriate dosing devices provided with the product
Indications
- Temporary relief of cough, congestion, and upper respiratory symptoms associated with the common cold
Mechanism of Action
- Combination of pharmacologic classes (e.g., antitussives suppress the cough center, expectorants thin bronchial secretions, decongestants cause vasoconstriction)
Contraindications
- Hypersensitivity to any active ingredient in the specific combination
- Concurrent use with or within 14 days of monoamine oxidase inhibitors (MAOIs)
- Severe hypertension or severe coronary artery disease (for formulations containing sympathomimetics)
Adverse Reactions
- Drowsiness or dizziness (antihistamine/sedative components)
- Insomnia, nervousness, or palpitations (sympathomimetic/decongestant components)
- Gastrointestinal upset, nausea, or dry mouth
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis
- Central nervous system (CNS) depressants/alcohol: enhanced sedation
- Other sympathomimetic agents: additive cardiovascular effects
Curated Content: Needs Vetting Before Put to Clinical Use