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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
cloperastine
R05DB21
Forms & Strengths
- Oral suspension: 0.1% (1 mg/mL)
- Oral syrup: 2 mg/mL
- Tablets: 10 mg, 20 mg
Adult Dosing
- Tablets: 10 mg to 20 mg orally three times daily
- Syrup/Suspension: 10 mL (10-20 mg) orally three times daily
- Maximum daily dose: 60 mg orally per day
Pediatric Dosing
- Children 2 to 6 years: 2 mL to 3 mL of syrup (2-3 mg) three times daily
- Children 7 to 15 years: 5 mL of syrup (5 mg) or 10 mg tablet three times daily
- Not recommended for children under 2 years of age
Indications
- Symptomatic treatment of non-productive (dry) cough
- Cough associated with upper respiratory tract infections
Mechanism of Action
- Acts centrally on the cough center in the medulla oblongata to suppress the cough reflex
- Exhibits mild anticholinergic and antihistaminic properties which contribute to its antitussive effect
Contraindications
- Hypersensitivity to cloperastine or any component of the formulation
- Concomitant use with monoamine oxidase inhibitors (MAOIs)
- Severe hepatic impairment
Adverse Reactions
- Somnolence and drowsiness
- Dry mouth
- Nausea or gastrointestinal discomfort
- Fatigue
- Hypersensitivity reactions (rare)
Drug Interactions
- Central nervous system (CNS) depressants (e.g., alcohol, sedatives, hypnotics): May potentiate sedative effects
- Anticholinergic agents: May enhance anticholinergic adverse effects such as dry mouth and urinary retention
- Monoamine oxidase inhibitors (MAOIs): May lead to enhanced central nervous system toxicity
Curated Content: Needs Vetting Before Put to Clinical Use