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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
tipepidine
R05DB24
Forms & Strengths
- Oral tablet: 10 mg
- Oral tablet: 20 mg
- Dry syrup: 2%
Adult Dosing
- Tipepidine hibenzate: 20 to 40 mg orally three times daily
- Tipepidine citrate: 13.5 to 27 mg (as tipepidine) orally three times daily
Pediatric Dosing
- Children 6 to 11 years: 10 mg orally three times daily (hibenzate salt)
- Children 3 to 5 years: 5 to 10 mg orally three times daily (hibenzate salt)
- Safety and efficacy in infants and neonates not well established
Indications
- Cough associated with common cold, acute bronchitis, and chronic bronchitis
- Suppression of non-productive cough
Mechanism of Action
- Acts centrally on the cough center in the medulla oblongata to elevate the cough threshold
- Possesses mild non-narcotic antitussive and expectorant properties
Contraindications
- Hypersensitivity to tipepidine or any components of the formulation
- Severe respiratory depression or acute respiratory failure
Adverse Reactions
- Drowsiness
- Nausea and vomiting
- Anorexia
- Rash or pruritus (hypersensitivity reactions)
- Dry mouth
Drug Interactions
- Central nervous system depressants (e.g., alcohol, sedatives, hypnotics): May potentiate sedative effects
- Monoamine oxidase inhibitors (MAOIs): Potential for pharmacodynamic interactions affecting CNS activity
Curated Content: Needs Vetting Before Put to Clinical Use