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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
levodropropizine
R05DB27
Forms & Strengths
- Oral syrup 2.5 mg/mL
- Tablets 30 mg
- Oral drops 1 mg per drop
- Solution for nebulization 5 mg/mL
Adult Dosing
- 30 mg (1 tablet) three times daily
- 10‑15 mL syrup (25‑37.5 mg) every 6‑8 h as needed
- Maximum 90 mg per day
Pediatric Dosing
- 0.5–1 mg/kg per dose every 6–8 h
- Maximum 30 mg per dose, 90 mg per day
- Syrup 5‑10 mL (12.5‑25 mg) depending on weight
- Not recommended for children <2 years
Indications
- Symptomatic relief of non‑productive cough
- Cough associated with upper respiratory tract infection
- Cough due to allergic rhinitis or post‑nasal drip
- Adjunct in chronic bronchitis with dry cough
Mechanism of Action
- Peripherally acting antitussive
- Inhibits sensory neuropeptide release from airway afferents
- Reduces cough reflex sensitivity without central depression
- Modulates transient receptor potential (TRP) channel activity
Contraindications
- Known hypersensitivity to levodropropizine or excipients
- Severe hepatic impairment
- Infants younger than 2 years
- Concurrent use of other antitussives containing codeine
Adverse Reactions
- Nausea and dyspepsia
- Headache or dizziness
- Mild skin rash or pruritus
- Rare hepatic enzyme elevation
- Transient taste alteration
Drug Interactions
- Additive cough suppression with other central antitussives
- May increase sedation with CNS depressants
- Caution with drugs metabolized by CYP2D6 (e.g., metoprolol)
- Avoid concomitant MAO‑inhibitors in patients on opioid cough suppressants
Curated Content: Needs Vetting Before Put to Clinical Use