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RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants
dimethoxanate
R05DB28
Forms & Strengths
- Oral syrup: 25 mg/5 mL
- Oral tablets: 20 mg
- Suppositories: 30 mg
Adult Dosing
- Oral: 20 mg to 40 mg three to four times daily
- Maximum daily dose: 160 mg
Pediatric Dosing
- Children 2 to 6 years: 10 mg two to three times daily
- Children 6 to 12 years: 20 mg two to three times daily
- Not recommended for infants under 2 years of age
Indications
- Symptomatic treatment of non-productive (dry) cough
Mechanism of Action
- Acts centrally as a non-narcotic antitussive to suppress the medullary cough center
- Possesses mild local anesthetic and antihistaminic properties
Contraindications
- Hypersensitivity to dimethoxanate or related compounds
- Severe respiratory insufficiency
- Productive cough where suppression may cause mucus retention
Adverse Reactions
- Drowsiness and sedation
- Dizziness
- Dry mouth
- Mild gastrointestinal disturbances (nausea, dyspepsia)
- Allergic skin reactions (rare)
Drug Interactions
- Central nervous system (CNS) depressants (alcohol, sedatives, hypnotics): May potentiate sedative effects
- Anticholinergic agents: May enhance anticholinergic side effects such as dry mouth
Curated Content: Needs Vetting Before Put to Clinical Use