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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Aminoalkyl ethers
bromazine
R06AA01
Forms & Strengths
- Oral tablets: 10 mg
- Elixir: 2 mg/mL
Adult Dosing
- Allergic conditions: 5 mg to 10 mg orally every 4 to 6 hours as needed
- Maximum daily dose: 60 mg
Pediatric Dosing
- Children 6 to 12 years: 2.5 mg to 5 mg orally every 4 to 6 hours as needed
- Maximum daily dose in children: 30 mg
- Not recommended for children under 6 years
Indications
- Symptomatic relief of allergic conditions including allergic rhinitis, urticaria, and pruritus
Mechanism of Action
- First-generation ethanolamine-class antihistamine that acts as an inverse agonist/antagonist at peripheral and central histamine H1 receptors
- Exhibits significant anticholinergic, sedative, and local anesthetic properties
Contraindications
- Hypersensitivity to bromazine or other ethanolamine antihistamines
- Narrow-angle glaucoma
- Symptomatic prostatic hypertrophy
- Stenosing peptic ulcer or pyloroduodenal obstruction
- Concurrent use with monoamine oxidase inhibitors (MAOIs)
Adverse Reactions
- Central nervous system depression, somnolence, sedation, dizziness, and cognitive impairment
- Anticholinergic effects including dry mouth, blurred vision, urinary retention, and constipation
- Tachycardia, palpitations, and orthostatic hypotension
- Paradoxical excitation in pediatric patients
Drug Interactions
- Potentiation of CNS depression when co-administered with alcohol, opioids, benzodiazepines, or other sedatives
- Enhancement of anticholinergic adverse effects when combined with tricyclic antidepressants or other anticholinergic agents
- May mask ototoxicity caused by aminoglycoside antibiotics
Curated Content: Needs Vetting Before Put to Clinical Use