← Search & browse all drugs
RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines
dexbrompheniramine, combinations
R06AB56
Forms & Strengths
- Oral syrup: Dexbrompheniramine maleate 2 mg / Pseudoephedrine sulfate 30 mg per 5 mL
- Extended-release tablets: Dexbrompheniramine maleate 6 mg / Pseudoephedrine sulfate 120 mg
Adult Dosing
- Extended-release tablet: 1 tablet orally every 12 hours
- Syrup: 5 mL to 10 mL orally every 4 to 6 hours as needed
- Maximum: Do not exceed 2 extended-release tablets in 24 hours
Pediatric Dosing
- Children 6 to 12 years (Extended-release): 1/2 tablet orally every 12 hours
- Children 6 to 12 years (Syrup): 2.5 mL to 5 mL orally every 4 to 6 hours
- Children under 6 years: Safety and efficacy not established in combination products
Indications
- Temporary relief of nasal congestion, sneezing, rhinorrhea, and lacrimation associated with allergic rhinitis or the common cold
Mechanism of Action
- Dexbrompheniramine: Competitive H1-receptor antagonist that blocks histamine effects, reducing allergic symptoms and providing anticholinergic drying
- Pseudoephedrine: Direct- and indirect-acting sympathomimetic amine that stimulates alpha-adrenergic receptors in the respiratory mucosa, causing vasoconstriction and reducing nasal congestion
Contraindications
- Hypersensitivity to dexbrompheniramine, pseudoephedrine, or other components
- Concurrent monoamine oxidase inhibitor (MAOI) therapy or within 14 days of stopping
- Severe hypertension or severe coronary artery disease
- Narrow-angle glaucoma, urinary retention, severe renal impairment
Adverse Reactions
- Central nervous system: Sedation, somnolence, dizziness, headache, insomnia (from decongestant component)
- Anticholinergic: Dry mouth, blurred vision, constipation, urinary hesitancy
- Cardiovascular: Palpitations, tachycardia, elevated blood pressure
Drug Interactions
- MAOIs: May cause hypertensive crisis; avoid concurrent use
- CNS depressants (alcohol, sedatives, tranquilizers): Potentiates sedative effects
- Sympathomimetic agents: May result in additive cardiovascular stimulation and increased blood pressure
- Anticholinergic drugs: May intensify anticholinergic side effects
Curated Content: Needs Vetting Before Put to Clinical Use