← Search & browse all drugs
RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted ethylene diamines
histapyrrodine, combinations
R06AC52
Forms & Strengths
- Fixed-dose combination tablets containing histapyrrodine hydrochloride and analgesics/antipyretics (varies by regional product)
Adult Dosing
- 1-2 tablets orally every 4 to 6 hours as needed for symptoms
- Maximum daily dose governed by the non-antihistamine combination components (e.g., paracetamol)
Pediatric Dosing
- Not recommended for children under 12 years of age due to fixed-dose combination safety risks
Indications
- Symptomatic relief of allergic rhinitis, common cold, and associated mild to moderate pain or fever
Mechanism of Action
- Histapyrrodine acts as a first-generation antihistamine via competitive histamine H1-receptor antagonism
- Combination agents provide synergistic analgesic and antipyretic effects
Contraindications
- Hypersensitivity to histapyrrodine or any component of the formulation
- Narrow-angle glaucoma
- Symptomatic prostate hypertrophy
- Severe hepatic or renal impairment
- Concomitant monoamine oxidase inhibitor (MAOI) therapy
Adverse Reactions
- Drowsiness, sedation, and fatigue
- Anticholinergic effects: dry mouth, blurred vision, urinary retention, constipation
- Dizziness, headache, and psychomotor impairment
- Gastrointestinal upset
Drug Interactions
- Potentiation of central nervous system depression with alcohol, sedatives, hypnotics, and anxiolytics
- Enhanced anticholinergic side effects when co-administered with tricyclic antidepressants or other anticholinergic drugs
- Risk of hypertensive crisis and severe adverse effects with MAO inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use