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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Piperazine derivatives
oxatomide
R06AE06
Forms & Strengths
- Tablets: 30 mg
- Syrup: 2.5 mg/mL
Adult Dosing
- Allergic rhinitis, conjunctivitis, urticaria: 30 mg orally twice daily after meals
- Max dose: 60 mg daily
Pediatric Dosing
- Children 1-6 years: 1 mg/kg daily divided in two doses
- Children > 6 years: 30 mg twice daily
Indications
- Allergic rhinitis
- Allergic conjunctivitis
- Chronic urticaria
- Allergic asthma (adjunctive therapy in some regions)
Mechanism of Action
- H1-receptor antagonist with slow dissociation rate
- Calcium channel antagonist properties
- Inhibits release of histamine and other allergic mediators from mast cells
Contraindications
- Hypersensitivity to oxatomide or piperazine derivatives
- Severe hepatic impairment
- Pregnancy and lactation
- Conditions predisposing to QT prolongation
Adverse Reactions
- Somnolence and sedation
- Weight gain and increased appetite
- Dry mouth
- Dizziness
- Nausea
- Extrapyramidal symptoms (rare, primarily in children)
Drug Interactions
- Central nervous system depressants (alcohol, sedatives, hypnotics): Enhanced sedation
- MAO inhibitors: Prolonged and intensified anticholinergic effects
- Drugs prolonging the QT interval: Increased risk of ventricular arrhythmias
Curated Content: Needs Vetting Before Put to Clinical Use