← Search & browse all drugs
RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Piperazine derivatives
cyclizine, combinations
R06AE53
Forms & Strengths
- Cyclizine hydrochloride 50 mg / Diphenhydramine combinations (oral tablets)
- Cyclizine combinations vary by regional formulation and OTC status
Adult Dosing
- Motion sickness / Nausea: 50 mg orally up to three times daily as needed
- Maximum daily dose: 150 mg per 24 hours
Pediatric Dosing
- Children 6 to 12 years: 25 mg orally up to three times daily as needed
- Not recommended for children under 6 years unless specifically directed by a physician
Indications
- Prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness
- Management of vertigo and labyrinthine disorders
Mechanism of Action
- Competitive antagonism of central and peripheral histamine H1 receptors
- Anticholinergic properties depress labyrinthine function and vestibulocerebellar pathways
Contraindications
- Hypersensitivity to cyclizine, diphenhydramine, or other antihistamines
- Narrow-angle glaucoma
- Severe hepatic impairment
- Symptoms of prostatic hypertrophy or urinary retention
Adverse Reactions
- Drowsiness, sedation, and fatigue
- Anticholinergic effects: dry mouth, blurred vision, urinary retention, and constipation
- Dizziness, headache, and paradoxical excitation in children
Drug Interactions
- Central nervous system depressants (alcohol, barbiturates, opioids, sedatives) enhance sedative effects
- Drugs with strong anticholinergic properties (tricyclic antidepressants, MAOIs) increase risk of anticholinergic toxicity
Curated Content: Needs Vetting Before Put to Clinical Use