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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
antazoline
R06AX05
Forms & Strengths
- Ophthalmic solution: Antazoline hydrochloride 0.5% combined with tetryzoline hydrochloride 0.05%
Adult Dosing
- Ophthalmic: Instill 1 to 2 drops in the affected eye(s) up to 4 times daily as needed for symptom relief
Pediatric Dosing
- Children < 2 years: Safety and efficacy not established
- Children >= 2 years: Instill 1 drop in the affected eye(s) up to 3 to 4 times daily under adult supervision
Indications
- Temporary relief of minor eye irritation and redness caused by allergens such as pollen, ragweed, grass, and animal dander
Mechanism of Action
- First-generation antihistamine that competitively blocks H1 receptors on conjunctival vessels and tissues
- Reduces histamine-mediated allergic symptoms including itching, vasodilation, and edema
- Formulated with a sympathomimetic decongestant (tetryzoline) to cause vasoconstriction and reduce conjunctival congestion
Contraindications
- Hypersensitivity to antazoline or any component of the formulation
- Presence of narrow-angle glaucoma or predisposition to angle closure
- Concurrent use with monoamine oxidase inhibitors (MAOIs)
Adverse Reactions
- Transient stinging or burning upon instillation
- Blurred vision
- Mydriasis (pupil dilation)
- Rebound hyperemia with prolonged use
- Systemic sympathomimetic effects (rare): hypertension, tachycardia, headache
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Concurrent use may precipitate hypertensive crisis due to the sympathomimetic component
- CNS depressants: May theoretically enhance sedative effects if absorbed systemically
Curated Content: Needs Vetting Before Put to Clinical Use