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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
azatadine
R06AX09
Adult Dosing
- Allergic rhinitis and chronic urticaria: 1 to 2 mg orally twice daily
Pediatric Dosing
- Children 12 years and older: 1 to 2 mg orally twice daily
- Children under 12 years: Safety and efficacy not established
Indications
- Symptomatic relief of perennial and seasonal allergic rhinitis
- Vasomotor rhinitis
- Allergic conjunctivitis
- Mild, uncomplicated allergic skin manifestations of urticaria and angioedema
Mechanism of Action
- First-generation piperidine-derivative antihistamine
- Acts as a selective antagonist of peripheral and central histamine H1 receptors
- Exhibits significant anticholinergic and moderate antiserotonergic properties
Contraindications
- Hypersensitivity to azatadine or other dibenzocycloheptene derivatives
- Use in newborns or premature infants
- Use in nursing mothers
- Concurrent treatment with monoamine oxidase inhibitors (MAOIs)
- Narrow-angle glaucoma, symptomatic prostatic hypertrophy, bladder neck obstruction, and stenosing peptic ulcer
Adverse Reactions
- Sedation, somnolence, fatigue, and dizziness
- Anticholinergic effects: dry mouth, blurred vision, urinary retention, and constipation
- Gastrointestinal distress: nausea, vomiting, and epigastric distress
- Paradoxical excitation in children
- Palpitations, tachycardia, and hypotension
Drug Interactions
- Central nervous system depressants (alcohol, barbiturates, hypnotics, sedatives, anxiolytics): enhanced CNS depression
- Monoamine oxidase inhibitors (MAOIs): prolonged and intensified anticholinergic effects of antihistamines
- Drugs with anticholinergic properties (tricyclic antidepressants, atropine): additive anticholinergic adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use