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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
mebhydrolin
R06AX15
Forms & Strengths
- Tablet 50 mg
- Tablet 100 mg
Adult Dosing
- 50 mg to 100 mg orally one to three times daily
- Maximum daily dose: 300 mg
Pediatric Dosing
- Children 6-12 years: 50 mg orally two times daily
- Children 2-5 years: 25 mg to 50 mg orally two times daily
Indications
- Allergic rhinitis
- Urticaria
- Allergic conjunctivitis
- Pruritic skin conditions
Mechanism of Action
- First-generation histamine H1-receptor antagonist
- Competitively blocks H1 receptors on target tissues, reducing histamine-induced pruritus, vasodilation, and increased vascular permeability
- Possesses mild anticholinergic and sedative properties
Contraindications
- Hypersensitivity to mebhydrolin or related compounds
- Neonates and premature infants
- Concurrent use with monoamine oxidase inhibitors (MAOIs)
- Narrow-angle glaucoma
- Symptomatic prostate hypertrophy
Adverse Reactions
- Drowsiness and sedation
- Dizziness
- Dry mouth, nose, and throat
- Blurred vision
- Urinary retention
- Gastrointestinal disturbances (nausea, constipation)
Drug Interactions
- Central nervous system depressants (alcohol, opioids, sedatives, hypnotics) increase sedative effects
- Anticholinergic drugs (tricyclic antidepressants, atropine) enhance anticholinergic adverse effects
- MAOIs may prolong and intensify the anticholinergic effects of antihistamines
Curated Content: Needs Vetting Before Put to Clinical Use