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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
deptropine
R06AX16
Forms & Strengths
- Oral tablets: 1 mg
- Syrup: 0.5 mg/5 mL
Adult Dosing
- Allergic conditions: 1 to 2 mg daily in divided doses
- Maximum daily dose: 6 mg
Pediatric Dosing
- Children > 1 year: 0.5 to 1 mg daily in divided doses based on age and weight
- Not recommended in neonates and infants under 1 year
Indications
- Allergic rhinitis
- Urticaria
- Pruritus
- Adjuvant treatment in respiratory tract conditions with bronchospasm
Mechanism of Action
- Competitive antagonism of histamine H1 receptors
- Possesses significant anticholinergic (antimuscarinic) and mild local anesthetic properties
- Reduces capillary permeability and smooth muscle contraction induced by histamine
Contraindications
- Hypersensitivity to deptropine or other dibenzocycloheptadiene derivatives
- Narrow-angle glaucoma
- Urinary retention secondary to prostatic hyperplasia or urethral stricture
- Pyloric obstruction or paralytic ileus
- Concurrent use with MAO inhibitors
Adverse Reactions
- Drowsiness, sedation, and fatigue
- Anticholinergic effects: dry mouth, blurred vision, constipation, and urinary retention
- Tachycardia and palpitations
- Dizziness, headache, and paradoxical excitation in children
Drug Interactions
- Enhancement of CNS depression when co-administered with alcohol, sedatives, hypnotics, or anxiolytics
- Potentiation of anticholinergic side effects with tricyclic antidepressants, MAO inhibitors, and antiparkinsonian drugs
- May mask ototoxicity symptoms caused by aminoglycoside antibiotics
Curated Content: Needs Vetting Before Put to Clinical Use