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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
azelastine
R06AX19
Forms & Strengths
- Nasal spray: 0.1% (137 mcg/spray)
- Nasal spray: 0.15% (205.5 mcg/spray)
- Ophthalmic solution: 0.05%
Adult Dosing
- Allergic rhinitis (0.1%): 2 sprays per nostril twice daily
- Allergic rhinitis (0.15%): 1 or 2 sprays per nostril once daily
- Vasomotor rhinitis: 2 sprays per nostril twice daily
- Allergic conjunctivitis: 1 drop in affected eye(s) twice daily
Pediatric Dosing
- Allergic rhinitis (0.1%): Children 6-11 years, 1 spray per nostril twice daily
- Allergic rhinitis (0.1% / 0.15%): Adolescents >=12 years, same as adult dosing
- Allergic conjunctivitis: Children >=3 or >=4 years (depending on formulation), 1 drop twice daily
Indications
- Seasonal allergic rhinitis
- Perennial allergic rhinitis
- Vasomotor rhinitis
- Allergic conjunctivitis
Mechanism of Action
- Selective H1-receptor antagonist
- Inhibits release of mast cell mediators (e.g., histamine, leukotrienes)
- Exhibits anti-inflammatory properties
Contraindications
- Hypersensitivity to azelastine or formulation components
Adverse Reactions
- Bitter taste (dysgeusia)
- Somnolence / fatigue
- Nasal burning or irritation
- Epistaxis
- Headache
- Transient eye stinging (ophthalmic)
Drug Interactions
- CNS depressants (alcohol, sedatives, hypnotics): Increased sedation
- Alcohol: Potential additive impairment of psychomotor performance
Curated Content: Needs Vetting Before Put to Clinical Use