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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
pimethixene
R06AX23
Forms & Strengths
- Oral tablet: 2.5 mg
- Oral syrup: 2.5 mg/5 mL
Adult Dosing
- Allergic conditions: 2.5 mg to 5 mg orally 3 times daily
- Maximum daily dose: 15 mg
Pediatric Dosing
- Children 2-6 years: 1.25 mg to 2.5 mg orally 2 to 3 times daily
- Children >6 years: 2.5 mg orally 2 to 3 times daily
Indications
- Symptomatic treatment of allergic conditions (e.g., allergic rhinitis, urticaria)
- Pruritic skin conditions
Mechanism of Action
- First-generation antihistamine with competitive antagonism at H1 histamine receptors
- Exhibits significant anticholinergic (antimuscarinic) and central nervous system sedative properties
Contraindications
- Hypersensitivity to pimethixene or other phenothiazine derivatives
- Narrow-angle glaucoma
- Risk of urinary retention related to urethroprostatic disorders
- Neonates and premature infants
Adverse Reactions
- Somnolence and sedation
- Anticholinergic effects: dry mouth, blurred vision, constipation, urinary retention
- Dizziness, confusion, or paradoxical excitation in pediatric patients
- Hypotension and palpitations
Drug Interactions
- Enhancement of central nervous system depression when co-administered with alcohol, opioids, sedatives, or hypnotics
- Potentiation of anticholinergic adverse effects when used with other antimuscarinic agents (e.g., tricyclic antidepressants, atropine)
Curated Content: Needs Vetting Before Put to Clinical Use