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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
bilastine
R06AX29
Forms & Strengths
- Tablet: 20 mg
- Oral solution: 10 mg/mL
Adult Dosing
- Allergic rhinitis and urticaria: 20 mg orally once daily, taken on an empty stomach (1 hour before or 2 hours after food/fruit juice)
Pediatric Dosing
- Children 6 to 11 years (weight ≥ 20 kg): 10 mg orally once daily as oral solution or 10 mg dispersible tablet, taken on an empty stomach
- Children under 6 years: Safety and efficacy not established
Indications
- Symptomatic treatment of seasonal and perennial allergic rhinitis
- Symptomatic treatment of chronic spontaneous urticaria
Mechanism of Action
- Selective, peripheral histamine H1-receptor antagonist
- Inhibits histamine-induced wheal and flare skin reactions
- Lacks significant central nervous system penetration, minimizing sedation
- Does not possess significant anticholinergic activity
Contraindications
- Hypersensitivity to bilastine or any excipients
Adverse Reactions
- Headache
- Somnolence
- Dizziness
- Fatigue
- Nausea
- Abdominal pain
Drug Interactions
- Ketoconazole or erythromycin: May increase plasma concentrations of bilastine via P-glycoprotein inhibition
- Diltiazem: May increase plasma concentrations of bilastine
- Food and grapefruit juice: Significantly decreases oral bioavailability of bilastine by at least 30%
Curated Content: Needs Vetting Before Put to Clinical Use