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RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use
sequifenadine
R06AX32
Forms & Strengths
- Oral tablets: 20 mg
- Oral tablets: 50 mg
Adult Dosing
- Allergic rhinitis and urticaria: 20 to 50 mg orally two to three times daily
- Maximum daily dose: 150 mg
Pediatric Dosing
- Children aged 6-12 years: 10 to 20 mg orally twice daily
- Safety and efficacy in children under 6 years not established
Indications
- Allergic rhinitis
- Urticaria
- Allergic conjunctivitis
- Pruritic skin conditions
Mechanism of Action
- Selective peripheral histamine H1-receptor antagonist
- Inhibits histamine-induced bronchoconstriction, vasodilation, and pruritus
- Possesses mild anticholinergic and antiserotonergic properties
Contraindications
- Hypersensitivity to sequifenadine or related antihistamines
- Severe hepatic impairment
- Concomitant use with monoamine oxidase inhibitors (MAOIs)
- Narrow-angle glaucoma
Adverse Reactions
- Somnolence and sedation
- Dry mouth, nose, and throat
- Dizziness and headache
- Gastrointestinal disturbance (nausea, dyspepsia)
- Urinary retention in susceptible patients
Drug Interactions
- Central nervous system depressants (alcohol, sedatives, hypnotics) enhance sedative effects
- Anticholinergic drugs increase risk of additive antimuscarinic side effects
- Hepatic enzyme inducers may decrease plasma concentrations of sequifenadine
Curated Content: Needs Vetting Before Put to Clinical Use