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RESPIRATORY SYSTEM › OTHER RESPIRATORY SYSTEM PRODUCTS › OTHER RESPIRATORY SYSTEM PRODUCTS › Respiratory stimulants
bemegride
R07AB05
Forms & Strengths
- Intravenous solution: 5 mg/mL (historical/withdrawn)
Adult Dosing
- Barbiturate overdose (historical): 50 mg IV repeated every 3 to 5 minutes until signs of anapnoic recovery, reflex return, or waking occur
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Barbiturate toxicity and overdose management (historical CNS respiratory stimulant)
- Termination of barbiturate anesthesia
Mechanism of Action
- Central nervous system stimulant acting as an antagonist to barbiturate-induced central depression
- Exerts convulsant properties at high doses through stimulation of the reticular activating system
Contraindications
- Known hypersensitivity to bemegride
- Severe anoxia or profound hypoxia without adequate ventilation
Adverse Reactions
- Generalized tonic-clonic seizures
- Nausea and vomiting
- Agitation and restlessness
- Cardiac arrhythmias and tachycardia
- Hypertension
Drug Interactions
- Additive central nervous system stimulation when combined with other analeptics or stimulants
- Antagonizes the hypnotic and respiratory depressant effects of barbiturates
Curated Content: Needs Vetting Before Put to Clinical Use