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oxytetracycline

S01AA04

Forms & Strengths

Ophthalmic Ointment: 1% (10 mg/g) with polymyxin B sulfate

Adult Dosing

Ophthalmic: Apply a small amount (approx. 0.5 inch ribbon) to the affected eye 2 to 4 times daily or more frequently depending on infection severity.

Pediatric Dosing

Ophthalmic: Apply a small amount to the affected eye 2 to 4 times daily (safety and efficacy established in pediatric patients for superficial ocular infections).

Indications

Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by susceptible organisms
Prophylaxis of ophthalmia neonatorum due to Neisseria gonorrhoeae or Chlamydia trachomatis

Mechanism of Action

Binds reversibly to the 30S ribosomal subunit of susceptible bacteria
Inhibits bacterial protein synthesis by preventing the access of aminoacyl-tRNA to the mRNA-ribosome complex
Bacteriostatic activity against a wide range of gram-positive and gram-negative organisms

Contraindications

Hypersensitivity to oxytetracycline or any component of the formulation
Hypersensitivity to other tetracyclines

Adverse Reactions

Transient stinging or burning upon application
Blurry vision immediately following administration
Allergic reactions including pruritus, swelling, and urticaria
Superinfection with non-susceptible organisms, including fungi, with prolonged use

Drug Interactions

Local antagonistic effects possible if combined with other bacteriostatic ophthalmic anti-infectives
Systemic absorption from ophthalmic use is minimal, making significant systemic drug interactions unlikely

Curated Content: Needs Vetting Before Put to Clinical Use