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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics
natamycin
S01AA10
Adult Dosing
- Fungal keratitis: 1 drop into conjunctival sac every 1 to 2 hours initially, then tapered to 1 drop 6 to 8 times daily as infection subsides; usual duration of therapy is 14 to 21 days
Pediatric Dosing
- Fungal keratitis (children ≥ 2 years): 1 drop into conjunctival sac every 1 to 2 hours initially, then tapered based on clinical response, similar to adult regimen
Indications
- Treatment of fungal keratitis caused by susceptible organisms including Fusarium solani
Mechanism of Action
- Polyene antifungal agent that binds to sterols (ergosterol) in the fungal cell membrane, altering membrane permeability and causing leakage of intracellular components
Contraindications
- Hypersensitivity to natamycin or any components of the formulation
Adverse Reactions
- Eye irritation
- Eye pain
- Blurred vision
- Foreign body sensation
- Hyperemia
- Allergic conjunctivitis
Drug Interactions
- No significant systemic drug interactions expected due to minimal systemic absorption following ophthalmic administration
- Concomitant use of other topical ophthalmic medications should be separated by at least 5 to 10 minutes
Curated Content: Needs Vetting Before Put to Clinical Use