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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics
rifamycin
S01AA16
Adult Dosing
- Instill 1 to 2 drops into the affected eye(s) 4 to 6 times daily, or as directed by a healthcare professional.
Pediatric Dosing
- Safety and efficacy in pediatric patients below a certain age have not been established; use as directed by an ophthalmologist.
Indications
- Treatment of superficial ocular infections (such as conjunctivitis) caused by susceptible organisms.
Mechanism of Action
- Inhibits bacterial RNA synthesis by binding to the beta-subunit of DNA-dependent RNA polymerase, thereby blocking RNA transcription.
Contraindications
- Hypersensitivity to rifamycin, other rifamycins (e.g., rifampin), or any component of the formulation.
Adverse Reactions
- Transient ocular irritation
- Burning or stinging upon instillation
- Allergic conjunctivitis
- Erythema
Drug Interactions
- Systemic absorption from ophthalmic administration is minimal; however, potential systemic interactions with strong CYP3A4 inducers or inhibitors cannot be entirely ruled out with concurrent systemic rifamycin use.
Curated Content: Needs Vetting Before Put to Clinical Use