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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics
azidamfenicol
S01AA25
Adult Dosing
- Instill 1 to 2 drops into the affected eye(s) 3 to 4 times daily
- Duration of treatment typically not to exceed 7-10 days
Pediatric Dosing
- Safety and efficacy in neonates and young children not rigorously established
- Use lowest effective dose if prescribed by an ophthalmologist for older children
Indications
- Bacterial conjunctivitis
- Superficial ocular infections caused by susceptible organisms
Mechanism of Action
- Broad-spectrum chloramphenicol analogue
- Inhibits bacterial protein synthesis by binding reversibly to the 50S ribosomal subunit
Contraindications
- Hypersensitivity to azidamfenicol or chloramphenicol
- History of bone marrow suppression or blood dyscrasias
- Fungal or viral ocular infections
Adverse Reactions
- Transient stinging or burning upon instillation
- Allergic contact dermatitis
- Hypersensitivity reactions
- Rare risk of systemic bone marrow toxicity with prolonged use
Drug Interactions
- Concomitant use with other myelosuppressive ophthalmic or systemic drugs should be avoided
- Potential antagonism with bactericidal antibiotics like penicillins or aminoglycosides in specific contexts
Curated Content: Needs Vetting Before Put to Clinical Use