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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics
vancomycin
S01AA28
Forms & Strengths
- Ophthalmic Solution: 50 mg/mL (5%)
Adult Dosing
- Severe ocular infections (e.g., bacterial keratitis, endophthalmitis): Instill 1 to 2 drops into the affected eye(s) every 1 to 2 hours initially, decreasing frequency as infection improves.
Pediatric Dosing
- Severe ocular infections: Instill 1 to 2 drops into the affected eye(s) every 1 to 2 hours initially, adjusted based on clinical severity and response.
Indications
- Treatment of severe ocular infections caused by susceptible Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
Mechanism of Action
- Binds to D-alanyl-D-alanine cell wall precursors, inhibiting bacterial cell wall synthesis and increasing cell membrane permeability.
Contraindications
- Hypersensitivity to vancomycin or any component of the formulation.
Adverse Reactions
- Transient ocular stinging or burning
- Blurred vision
- Hyperemia
- Allergic contact dermatitis
- Corneal epitheliopathy (with prolonged use)
Drug Interactions
- Concomitant use of other nephrotoxic or ototoxic topical ocular agents with systemic absorption potential requires monitoring.
- Potential precipitation if mixed directly in solution with certain beta-lactam antibiotics or corticosteroids.
Curated Content: Needs Vetting Before Put to Clinical Use