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sulfamethizole

S01AB01

Forms & Strengths

Ophthalmic drops: 4% (as sulfamethizole sodium)

Adult Dosing

Instill 1 to 2 drops into the affected eye(s) up to 4 to 6 times daily, or more frequently depending on the severity of the infection.

Pediatric Dosing

Children > 2 months: Instill 1 to 2 drops into the affected eye(s) up to 4 to 6 times daily, or as directed by physician.

Indications

Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by susceptible microorganisms.

Mechanism of Action

Competitively inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for the enzyme dihydropteroate synthetase, resulting in bacteriostasis.

Contraindications

Hypersensitivity to sulfonamides or any component of the formulation
Viral and fungal diseases of the ocular cornea and conjunctiva

Adverse Reactions

Transient stinging or burning upon instillation
Local irritation
Pruritus
Eyelid hyperemia
Hypersensitivity reactions

Drug Interactions

Local anesthetics containing PABA (e.g., tetracaine) may antagonize the antibacterial activity of sulfonamides
Incompatible with silver preparations

Curated Content: Needs Vetting Before Put to Clinical Use