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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Sulfonamides
sulfafurazole
S01AB02
Adult Dosing
- Conjunctivitis: Instill 1 to 2 drops into the affected eye(s) up to 4 to 6 times daily or more frequently as severe conditions require.
Pediatric Dosing
- Conjunctivitis (infants > 2 months and children): Instill 1 to 2 drops into the affected eye(s) up to 4 to 6 times daily or as directed by physician.
Indications
- Treatment of superficial ocular infections of the conjunctiva and/or cornea caused by susceptible microorganisms.
Mechanism of Action
- Competitive inhibition of bacterial para-aminobenzoic acid (PABA) utilization, preventing folic acid synthesis required for bacterial nucleic acid synthesis.
Contraindications
- Hypersensitivity to sulfonamides or any component of the formulation
- Neonates under 2 months of age due to risk of kernicterus
Adverse Reactions
- Transient stinging or burning upon instillation
- Local irritation
- Hypersensitivity reactions including contact dermatitis, pruritus, and angioedema
Drug Interactions
- Local anesthetics containing PABA (e.g., tetracaine) may antagonize the antibacterial activity of sulfonamides
- Incompatible with silver preparations in ophthalmic applications
Curated Content: Needs Vetting Before Put to Clinical Use