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sulfafenazol

S01AB05

Forms & Strengths

ophthalmic solution 10% w/v
ophthalmic ointment 5% w/v

Adult Dosing

Conjunctivitis: 1 drop into affected eye(s) QID
Keratitis/corneal ulcer: 1 drop every 2 h for 48 h then QID until resolution

Pediatric Dosing

<2 y: 1 drop QID (avoid ointment)
2–12 y: 1 drop QID; severe keratitis: 1 drop every 2 h for 24 h then QID

Indications

Bacterial conjunctivitis
Blepharitis caused by susceptible organisms
Keratitis and corneal ulcer secondary to susceptible bacteria
Post‑operative prophylaxis in ocular surgery

Mechanism of Action

Reversibly inhibits dihydropteroate synthase, blocking bacterial folic‑acid synthesis; bacteriostatic

Contraindications

Known hypersensitivity to sulfonamides or sulfafenazol
Pregnancy – first trimester and breastfeeding
Severe hepatic or renal impairment when systemic absorption is significant

Adverse Reactions

Local burning, stinging or itching
Allergic conjunctivitis with hyperemia
Photophobia, photosensitivity
Systemic sulfonamide reactions – rash, Stevens‑Johnson syndrome, hemolysis in G6PD deficiency

Drug Interactions

Concurrent systemic sulfonamides – additive toxicity
Warfarin – increased INR
Methotrexate – reduced clearance, increased toxicity
Phenobarbital, phenytoin – may increase sulfonamide metabolism

Curated Content: Needs Vetting Before Put to Clinical Use