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interferon

S01AD05

Forms & Strengths

Ophthalmic solution: 1 million IU/mL (interferon alfa)

Adult Dosing

Viral keratitis / Conjunctivitis: 1 drop instilled into the affected eye(s) 4 to 6 times daily for up to 14 days or until clinical resolution.

Pediatric Dosing

Safety and efficacy not established; use in pediatric patients is off-label and determined by specialist discretion.

Indications

Treatment of viral eye infections, specifically viral keratitis and viral conjunctivitis (e.g., adenovirus, herpes simplex virus).

Mechanism of Action

Binds to specific cell-surface receptors, initiating intracellular signaling that induces antiviral proteins (e.g., 2',5'-oligoadenylate synthetase, protein kinase R), inhibiting viral replication and modulating immune responses.

Contraindications

Hypersensitivity to natural or recombinant human interferons or any component of the formulation
Severe pre-existing autoimmune disease

Adverse Reactions

Transient ocular burning or stinging upon instillation
Blurred vision
Conjunctival hyperemia
Lacrimation
Rarely, allergic contact dermatitis or punctate keratitis

Drug Interactions

Immunosuppressive agents: May antagonize the antiviral or immunomodulatory effects of topical interferon
Other ophthalmic medications: Allow at least a 5-minute interval between multiple topical eye drops to prevent washout

Curated Content: Needs Vetting Before Put to Clinical Use