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norfloxacin

S01AE02

Forms & Strengths

0.3% ophthalmic solution (single‑dose vial)
0.1% ophthalmic solution (single‑dose vial)

Adult Dosing

Instill 1 drop in the affected eye(s) every 2 h while awake for the first 48 h, then every 4 h for 5‑7 days
Do not exceed 8 drops per day per eye

Pediatric Dosing

Same regimen as adults for children ≥1 month old, provided body weight >5 kg
For infants <1 month or <5 kg, safety not established; use only if benefit outweighs risk

Indications

Acute bacterial conjunctivitis caused by susceptible strains
Bacterial keratitis and corneal ulceration due to susceptible organisms

Mechanism of Action

Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, preventing DNA replication and transcription

Contraindications

Known hypersensitivity to norfloxacin or any fluoroquinolone
Viral, fungal, or allergic conjunctivitis

Adverse Reactions

Transient ocular burning, stinging, or tearing
Conjunctival hyperemia
Epithelial keratitis or corneal edema (rare)
Allergic conjunctivitis with eyelid edema

Drug Interactions

Concurrent systemic fluoroquinolones may increase risk of CNS toxicity (seizures, tremor)
Topical corticosteroids may mask infection progression
Anticholinergic eye drops may reduce pupil dilation, potentially affecting drug distribution

Curated Content: Needs Vetting Before Put to Clinical Use