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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFLAMMATORY AGENTS › Corticosteroids, plain
alclometasone
S01BA10
Forms & Strengths
- Ointment 0.05%
- Cream 0.05%
Adult Dosing
- Apply a thin film to the affected skin area 2 to 3 times daily
- Gently rub in
- Limit use to continuous periods of 2 weeks or less
Pediatric Dosing
- Children >= 1 year: Apply thin film to affected area 2 to 3 times daily
- Limit duration to minimize systemic absorption and hypothalamic-pituitary-adrenal axis suppression
- Safety and efficacy in infants < 1 year not established
Indications
- Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Mechanism of Action
- Low-to-medium potency topical corticosteroid
- Induces phospholipase A2 inhibitory proteins (lipocortins)
- Controls biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes
Contraindications
- Hypersensitivity to alclometasone or any component of the formulation
- Viral skin infections (e.g., varicella, herpes simplex)
- Fungal or bacterial skin infections without concurrent anti-infective therapy
- Rosacea and perioral dermatitis
Adverse Reactions
- Burning and stinging
- Pruritus
- Erythema
- Dry skin
- Skin atrophy and striae
- Hypopigmentation
- Hypertrichosis
- Secondary infection
Drug Interactions
- No significant pharmacokinetic drug interactions typically reported with topical administration
- Concomitant use with other potent topical corticosteroids may increase risk of systemic toxicity
- CYP3A4 inhibitors (if significant systemic absorption occurs)
Curated Content: Needs Vetting Before Put to Clinical Use