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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFLAMMATORY AGENTS › Corticosteroids, plain
rimexolone
S01BA13
Forms & Strengths
- Ophthalmic suspension 1% (Vexol)
Adult Dosing
- Post-operative inflammation: 1 to 2 drops into conjunctival sac of affected eye(s) 4 times daily, beginning 24 hours after surgery and continuing for 2 weeks
- Uveitis: 1 to 2 drops into conjunctival sac up to 4 times daily; severe cases may require hourly drops during the first week, tapering as inflammation subsides
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of postoperative inflammation following ocular surgery
- Treatment of anterior uveitis
Mechanism of Action
- Corticosteroid that inhibits the inflammatory response to a variety of inciting agents, suppressing edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation
Contraindications
- Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
- Mycobacterial infection of the eye
- Fungal diseases of ocular structures
- Hypersensitivity to rimexolone or any component of the formulation
Adverse Reactions
- Blurred vision
- Discharge
- Discomfort
- Foreign body sensation
- Hyperemia
- Pruritus
- Elevated intraocular pressure with possible optic nerve damage
- Posterior subcapsular cataract formation
- Delayed wound healing
- Secondary ocular infection (fungal and viral)
Drug Interactions
- No specific systemic drug interactions are well-documented for topical ophthalmic rimexolone due to minimal systemic absorption
- Concomitant use of topical NSAIDs and topical corticosteroids may increase the potential for healing complications in susceptible patients
Curated Content: Needs Vetting Before Put to Clinical Use