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clobetasol

S01BA17

Forms & Strengths

Ophthalmic suspension 0.05%

Adult Dosing

Instill 1 drop into the conjunctival sac of the affected eye 2 to 4 times daily
Duration of therapy ranges from several days to several weeks based on clinical response

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established

Indications

Treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe

Mechanism of Action

Potent corticosteroid that inhibits the inflammatory response to a variety of agents, delaying or slowing healing
Induces phospholipase A2 inhibitory proteins (lipocortins), controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes

Contraindications

Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
Mycobacterial infection of the eye
Fungal diseases of ocular structures
Hypersensitivity to any component of the medication

Adverse Reactions

Elevation of intraocular pressure (IOP) with possible development of glaucoma
Posterior subcapsular cataract formation
Delayed wound healing
Secondary ocular infection (bacterial, fungal, and viral)
Transient stinging or burning upon instillation

Drug Interactions

Concomitant use of topical anticholinergics may lead to increased intraocular pressure
Prolonged use with other topical ophthalmic drops may decrease absorption or increase systemic exposure

Curated Content: Needs Vetting Before Put to Clinical Use