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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFLAMMATORY AGENTS › Antiinflammatory agents, non-steroids
oxyphenbutazone
S01BC02
Forms & Strengths
- Ophthalmic ointment 10 mg/g
Adult Dosing
- Apply a small amount to the conjunctival sac 3 to 4 times daily
Pediatric Dosing
- Safety and efficacy not established in children; use with extreme caution
Indications
- Inflammatory conditions of the anterior segment of the eye
- Post-operative ocular inflammation
- Non-infected ocular trauma
Mechanism of Action
- Inhibits prostaglandin synthesis by decreasing cyclooxygenase activity, reducing ocular inflammation, pain, and vasodilation
Contraindications
- Hypersensitivity to oxyphenbutazone or phenylbutazone
- Epithelial herpes simplex keratitis (dendritic keratitis)
- Vaccinia, varicella, and other viral diseases of the cornea and conjunctiva
- Mycobacterial or fungal infections of the eye
Adverse Reactions
- Transient stinging or burning upon application
- Blurred vision
- Delayed corneal wound healing
- Increased intraocular pressure with prolonged use
- Secondary ocular infection
Drug Interactions
- Topical corticosteroids (may increase risk of corneal thinning and delayed healing)
- Other topical ophthalmic NSAIDs (may potentiate adverse corneal effects)
Curated Content: Needs Vetting Before Put to Clinical Use