← Search & browse all drugs
SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFLAMMATORY AGENTS › Antiinflammatory agents, non-steroids
diclofenac
S01BC03
Adult Dosing
- Postoperative inflammation after cataract surgery: 1 drop into the affected eye 4 times daily beginning 24 hours prior to surgery and continuing through the first 2 weeks of the postoperative period
- Photophobia following keratectomy: 1 drop into the affected eye every hour while awake for 24 hours preoperatively, or 1 drop 4 times daily as needed postoperatively
- Pain and inflammation after corneal refractive surgery: 1 to 2 drops into the affected eye within the hour prior to surgery, 1 drop within 15 minutes after surgery, and then 1 drop 4 times daily for up to 3 days
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of postoperative inflammation in patients who have undergone cataract surgery
- Temporary relief of pain and photophobia in patients undergoing corneal refractive surgery
Mechanism of Action
- Nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2) enzymes
- Decreases synthesis of prostaglandins, which are mediators of inflammation and pain
Contraindications
- Hypersensitivity to diclofenac sodium or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Adverse Reactions
- Transient burning and stinging upon instillation
- Keratitis
- Elevated intraocular pressure
- Iritis
- Allergic reactions and conjunctival hyperemia
Drug Interactions
- Concomitant use of topical NSAIDs and topical steroids may delay corneal healing
- Potential for additive effects when used with other drugs that prolong bleeding time or inhibit platelet aggregation
Curated Content: Needs Vetting Before Put to Clinical Use