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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFLAMMATORY AGENTS › Antiinflammatory agents, non-steroids
flurbiprofen
S01BC04
Forms & Strengths
- Ophthalmic solution: 0.03%
Adult Dosing
- Inhibition of intraoperative miosis: Instill 1 drop into the affected eye approximately every 30 minutes, beginning 2 hours prior to surgery (total of 4 drops)
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Inhibition of intraoperative miosis during cataract surgery
Mechanism of Action
- Nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin biosynthesis by decreasing the activity of the enzyme cyclooxygenase (COX), thereby preventing miosis induced during ocular surgery
Contraindications
- Hypersensitivity to flurbiprofen or any component of the formulation
- Epithelial herpes simplex keratitis
Adverse Reactions
- Transient burning and stinging upon instillation
- Mydriasis
- Ocular irritation
- Increased bleeding tendency of ocular tissues during surgery
Drug Interactions
- Acetylcholine chloride or carbachol: Concomitant use may render these cholinergic agents ineffective
- Ocular hypotensive agents: Potential for additive reduction in intraocular pressure
Curated Content: Needs Vetting Before Put to Clinical Use