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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION › Corticosteroids/antiinfectives/mydriatics in combination
betamethasone
S01CB04
Forms & Strengths
- Ophthalmic suspension 0.1%
- Ophthalmic ointment 0.1%
Adult Dosing
- Instill 1 to 2 drops into the conjunctival sac up to 4 to 6 times daily
- Apply a small amount of ointment to the conjunctival sac 3 to 4 times daily
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe
Mechanism of Action
- Glucocorticoid that decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability
Contraindications
- Epithelial herpes simplex keratitis (dendritic keratitis)
- Vaccinia and varicella and other viral diseases of the cornea and conjunctiva
- Mycobacterial infection of the eye
- Fungal diseases of ocular structures
- Hypersensitivity to betamethasone or any component
Adverse Reactions
- Elevation of intraocular pressure with possible development of glaucoma
- Posterior subcapsular cataract formation
- Delayed wound healing
- Secondary ocular infection from bacteria, fungi, or viruses
- Stinging and burning upon instillation
Drug Interactions
- Concomitant use of topical NSAIDs may delay corneal healing
- Prolonged systemic absorption may interact with CYP3A4 inhibitors (though minimal with ophthalmic route)
Curated Content: Needs Vetting Before Put to Clinical Use