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fluorometholone

S01CB05

Forms & Strengths

Ophthalmic suspension 0.1%
Ophthalmic suspension 0.25%
Ophthalmic ointment 0.1%

Adult Dosing

Suspension: Instill 1 to 2 drops into the conjunctival sac 2 to 4 times daily
Ointment: Apply a small amount (about 1/2 inch ribbon) to the conjunctival sac 1 to 3 times daily
May be increased to every 2 hours during the initial 24 to 48 hours for severe inflammation

Pediatric Dosing

Safety and efficacy in pediatric patients below 2 years of age have not been established
Children >= 2 years: Dosage is the same as for adults

Indications

Treatment of corticosteroid-responsive inflammation of the palpal and bulbar conjunctiva, cornea, and anterior segment of the globe

Mechanism of Action

Glucocorticoid receptor agonist that inhibits the inflammatory response to a variety of agents
Suppresses the migration of polymorphonuclear leukocytes, decreases capillary permeability, reverses vascular dilation, and inhibits fibroblast proliferation and collagen deposition

Contraindications

Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
Mycobacterial infection of the eye
Fungal diseases of ocular structures
Hypersensitivity to any component of the formulation

Adverse Reactions

Increased intraocular pressure (IOP) with possible optic nerve damage
Posterior subcapsular cataract formation
Secondary ocular infection from pathogens including herpes simplex and fungi
Delayed wound healing
Transient stinging and burning upon instillation
Blurred vision

Drug Interactions

Concomitant use of anticholinergics may increase intraocular pressure
Prolonged use with local anesthetics may cause permanent corneal damage
CYP3A4 inhibitors (e.g., ritonavir, cobicistat) may theoretically increase systemic exposure, though unlikely with ophthalmic application

Curated Content: Needs Vetting Before Put to Clinical Use